Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.70 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | KRAS | P01116 | 1/20 | 0.63 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.63 |
| ▸ | CNR1 | P21554 | 4/20 | 0.60 |
| ▸ | CNR2 | P34972 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.57 |
| ▸ | PRKDC | P78527 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13170943 | 1.00 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL9921358 | 1.00 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL8975390 | 0.89 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL8974915 | 0.89 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL8975191 | 0.89 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL13283262 | 0.85 | GALR3 (0.72) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL31505701 | 0.85 | GALR3 (0.72) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL31505705 | 0.85 | GALR3 (0.72) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL24577013 | 0.84 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 | |
| SCHEMBL6992336 | 0.84 | GALR3 (0.70) | GALR3NR2F2EGFRKRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | GALR3 1497/4885NR2F2 2764/4885EGFR 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.