Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327519 | 0.89 | KMT2A (0.49) | BTKNEK1ALDH1A1HPGDKMT2A | |
| SCHEMBL1327744 | 0.89 | NEK1 (0.42) | BTKNEK1ALDH1A1KMT2AMAP4K4 | |
| SCHEMBL1327814 | 0.85 | BTK (0.47) | BTKJAK2JAK3JAK1TYK2 | |
| SCHEMBL27847620 | 0.84 | NUDT1 (0.38) | BTKNEK1HPGDJAK2JAK3 | |
| SCHEMBL1328119 | 0.83 | NUDT1 (0.37) | BTKNEK1JAK2JAK3JAK1 | |
| SCHEMBL1328116 | 0.82 | NUDT1 (0.44) | JAK2JAK3JAK1TYK2AURKB | |
| SCHEMBL1327513 | 0.82 | NUDT1 (0.37) | BTKNEK1HPGDJAK2JAK3 | |
| SCHEMBL1328371 | 0.82 | ANO1 (0.40) | BTKALDH1A1JAK2JAK3AURKB | |
| SCHEMBL1328693 | 0.81 | JAK1 (0.41) | BTKJAK2JAK3JAK1TYK2 | |
| SCHEMBL12127216 | 0.81 | NEK1 (0.56) | BTKNEK1ALDH1A1HPGDJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | claimed |
| CN-101918079-A | Protein kinase inhibitors and use thereof | MERCK SERONO SA | 2010-12-15 | — | — | CN | claimed |
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
| CN-101918079-A | Protein kinase inhibitors and use thereof | MERCK SERONO SA | 2010-12-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP3K19, MAP3K20, MAP3K1 | BTK 178/4885NEK1 224/4885ALDH1A1 3339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.