Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 11/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12224242 | 0.89 | MET (0.41) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL12245595 | 0.89 | SMN1; SMN2 (0.39) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL14724354 | 0.83 | MET (0.36) | LMNASMN1; SMN2NPSR1MET | |
| SCHEMBL12224229 | 0.81 | SMN1; SMN2 (0.48) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL12224243 | 0.81 | MET (0.47) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL12245312 | 0.79 | MET (0.44) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL2458149 | 0.79 | MET (0.44) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL12224218 | 0.77 | SMN1; SMN2 (0.40) | LMNATSHRHTTSMN1; SMN2NPSR1 | |
| SCHEMBL2529571 | 0.73 | MET (0.46) | TSHRMET | |
| SCHEMBL12224262 | 0.71 | MET (0.38) | SMN1; SMN2NPSR1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072301-A1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-01 | — | — | WO | disclosed |