Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.35 |
| ▸ | FPR3 | P25089 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | PTPRB | P23467 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2550148 | 0.89 | ATM (0.35) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL2550153 | 0.89 | ATM (0.35) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL4298661 | 0.89 | ATM (0.35) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL4303579 | 0.87 | PPARG (0.39) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL2550327 | 0.87 | ATM (0.38) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL4303581 | 0.87 | PPARG (0.39) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL2550321 | 0.87 | ATM (0.38) | ATMAAK1CTSSCTSKCYP3A4 | |
| SCHEMBL12241479 | 0.86 | USP30 (0.34) | FPR3FPR2 | |
| SCHEMBL2550412 | 0.86 | MLYCD (0.39) | ATMAAK1FPR3FPR2CTSS | |
| SCHEMBL1742109 | 0.85 | ATM (0.37) | ATMAAK1CTSSCTSKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |