MLYCD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL647139	1.00	20/20
SCHEMBL647659	1.00	20/20
SCHEMBL647994	1.00	20/20
SCHEMBL649339	1.00	20/20
SCHEMBL649300	0.75	20/20
SCHEMBL647138	0.70	20/20
SCHEMBL648037	0.69	20/20
SCHEMBL649533	0.67	20/20
SCHEMBL648813	0.62	20/20
SCHEMBL650108	0.58	20/20
SCHEMBL649056	0.55	20/20
SCHEMBL647661	0.53	20/20
SCHEMBL650860	0.52	20/20
SCHEMBL647634	0.52	19/20
SCHEMBL250966	0.58	18/20
SCHEMBL650015	0.54	17/20
SCHEMBL591541	0.47	16/20
Trifluoroacetic Acid (SCHEMBL22713)	0.39	15/20
SCHEMBL649587	0.50	14/20
SCHEMBL650043	0.56	13/20

Clinical trials — most relevant to MLYCD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:	PHASE3	ACTIVE_NOT_RECRUITING
Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis	PHASE3	COMPLETED
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells	PHASE1	RECRUITING
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation	nan	COMPLETED
The Prevalence of Metabolic Liver Disorders in Children	nan	UNKNOWN
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Photobiomodulation & Ketogenic Diet for Treatment of Mid-periphery Retinal Disorders for Alzheimer's Disease Prevention	nan	UNKNOWN
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Metabolic Effects of Medium-Chain Fatty Acids in Patients With Medium-Chain Acyl-CoA Dehydrogenase Deficiency and Healthy Individuals	nan	RECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults	nan	NOT_YET_RECRUITING
Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2	nan	UNKNOWN
Nephroprotective Effects of Carnitine and (PDE5) Inhibitor Agent Against Contrast Media-induced Nephropathy (CMN)	nan	UNKNOWN
The Effect of Lowered Physical Activity on Insulin Sensitivity and Lipid and Glucose Metabolism	nan	COMPLETED
Cardiac Manifestation and Inherited Metabolic Diseases	nan	COMPLETED
Mitochondrial Dysfunction in Autism Spectrum Disorder	nan	ACTIVE_NOT_RECRUITING
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Lactate Profile and Fat Oxidation During Exercise	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MLYCD binder may also engage these)

Protein	Name	Similarity
Q99J39	—	1.000	Q99J39 →
Q920F5	—	1.000	Q920F5 →
P12617	—	0.999	P12617 →
Q9BVI4	—	0.988	Q9BVI4 →
C5WNV2	—	0.987	C5WNV2 →
P06623	—	0.986	P06623 →
A7MBC2	—	0.986	A7MBC2 →
KAT8	Histone acetyltransferase KAT8	0.986	landscape →
KDM5B	Lysine-specific demethylase 5B	0.986	landscape →
KDM5D	Lysine-specific demethylase 5D	0.986	landscape →
Q66HY8	—	0.985	Q66HY8 →
D3ZEY4	—	0.985	D3ZEY4 →
Q9STV0	—	0.985	Q9STV0 →
TBCD	Tubulin-specific chaperone D	0.985	landscape →
A0A1D5AG16	—	0.985	A0A1D5AG16 →
Q5BJS0	—	0.985	Q5BJS0 →
Q8BHY2	—	0.985	Q8BHY2 →
Q5F259	—	0.984	Q5F259 →
Q5XUN4	—	0.984	Q5XUN4 →
F6S9E6	—	0.984	F6S9E6 →
B9IJ21	—	0.984	B9IJ21 →
Q9VDQ7	—	0.984	Q9VDQ7 →
Q90830	—	0.984	Q90830 →
Q8LI34	—	0.984	Q8LI34 →
Q61586	—	0.984	Q61586 →
Q6P996	—	0.984	Q6P996 →
Q1PS67	—	0.984	Q1PS67 →
A1A5V9	—	0.984	A1A5V9 →
P41230	—	0.984	P41230 →
Q6UB35	—	0.984	Q6UB35 →