Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.60 |
| ▸ | GSK3B | P49841 | 6/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953226 | 0.89 | CDK2 (0.75) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL13304886 | 0.89 | CDK2 (0.47) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL12953883 | 0.86 | CDK2 (0.57) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL12952846 | 0.83 | GSK3B (0.70) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL14545801 | 0.82 | CDK2 (0.71) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL14301219 | 0.82 | CDK2 (0.64) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL12952883 | 0.82 | CDK2 (0.76) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL12953329 | 0.81 | CDK2 (0.58) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL12952920 | 0.79 | CDK2 (0.70) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL13305328 | 0.79 | CDK2 (0.70) | CDK2CCNE1GSK3BCCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |