Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | AGPAT2 | O15120 | 6/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16380596 | 0.82 | POLA1 (0.75) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL3450546 | 0.81 | AGPAT2 (0.70) | POLA1MAPTSMN1; SMN2POLBKMT2A | |
| SCHEMBL5308695 | 0.81 | ROCK1 (0.61) | POLA1ROCK2CA12CA1CA2 | |
| SCHEMBL28229117 | 0.76 | POLA1 (0.67) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL29609567 | 0.76 | POLA1 (0.67) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL3233125 | 0.76 | MAPT (0.70) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL3450227 | 0.76 | MAPT (0.57) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL4277487 | 0.76 | POLA1 (0.61) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL1320467 | 0.76 | KMT2A (0.66) | POLA1MAPTSMN1; SMN2GAAPOLB | |
| SCHEMBL17815607 | 0.75 | ROCK1 (0.61) | POLA1MAPTSMN1; SMN2GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |