Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | AGPAT2 | O15120 | 10/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13064960 | 0.88 | POLA1 (0.57) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL12346224 | 0.85 | POLA1 (0.62) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL7741592 | 0.85 | POLA1 (0.62) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL7746369 | 0.83 | POLA1 (0.59) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL3233125 | 0.83 | MAPT (0.70) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL13288394 | 0.82 | POLA1 (0.75) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL14050066 | 0.79 | POLA1 (0.61) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL29608945 | 0.79 | POLA1 (0.61) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL13963086 | 0.77 | CYP1A2 (0.72) | POLA1MAPTPOLBGAASMN1; SMN2 | |
| SCHEMBL28229117 | 0.76 | POLA1 (0.67) | POLA1MAPTPOLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921376-B2 | Pyrrolopyridines useful as inhibitors of protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-12-30 | — | — | US | disclosed |