Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 5/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27679617 | 0.93 | NPC1 (0.52) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL8271583 | 0.86 | HDAC2 (0.68) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL13288519 | 0.84 | HDAC1 (0.64) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL13288500 | 0.83 | HDAC2 (0.61) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL14298774 | 0.81 | HDAC2 (0.62) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL8269683 | 0.81 | HDAC2 (0.57) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL8270619 | 0.81 | HDAC8 (0.57) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL13288515 | 0.80 | HDAC2 (0.63) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL8270608 | 0.80 | HDAC2 (0.58) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL13294815 | 0.80 | HDAC2 (0.58) | HDAC1HDAC2HDAC3HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737184-B2 | Histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-15 | — | — | US | disclosed |
| US-7737184-B2 | Histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-06-15 | — | — | US | disclosed |
| US-20080033015-A1 | Histone Deacetylase Inhibitors | MERCK SHARP & DOHME LLC | 2008-02-07 | — | — | US | disclosed |
| US-20080033015-A1 | Histone Deacetylase Inhibitors | MERCK SHARP & DOHME LLC | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033015-A1 | Histone Deacetylase Inhibitors | HDAC1, HDAC5, HDAC9 | HDAC1 1/4885HDAC2 8/4885HDAC3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.