Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305706 | 0.92 | GSK3B (0.54) | GSK3BCDK2NTRK1CCNA2CCNA1 | |
| SCHEMBL12953516 | 0.91 | GSK3B (0.66) | GSK3BCDK2NTRK1CCNA2CCNA1 | |
| SCHEMBL14545221 | 0.87 | GSK3B (0.61) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL14050928 | 0.83 | GSK3B (0.61) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL13305702 | 0.83 | GSK3B (0.53) | GSK3BCDK2NTRK1CCNA2CCNA1 | |
| SCHEMBL13305704 | 0.83 | GSK3B (0.53) | GSK3BCDK2CCNA2CCNA1MAP4K1 | |
| SCHEMBL12953772 | 0.82 | GSK3B (0.68) | GSK3BCDK2CCNA2CCNA1MAP4K1 | |
| SCHEMBL12953665 | 0.80 | GSK3B (0.63) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL13305409 | 0.79 | GSK3B (0.58) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL14050780 | 0.79 | GSK3B (0.60) | GSK3BCDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |