Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305706 | 0.91 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1MAPK10 | |
| SCHEMBL13305704 | 0.90 | GSK3B (0.53) | GSK3BCDK2CCNA2CCNA1MAPK10 | |
| SCHEMBL13118559 | 0.90 | GSK3B (0.67) | GSK3BCDK2CCNA2CCNA1MAPK10 | |
| SCHEMBL14043304 | 0.87 | GSK3B (0.49) | GSK3BCDK2HPGDNAMPTKDM4E | |
| SCHEMBL12953665 | 0.85 | GSK3B (0.63) | GSK3BCDK2CCNA2CCNA1MEN1 | |
| SCHEMBL14050780 | 0.85 | GSK3B (0.60) | GSK3BCDK2CCNA2CCNA1HDAC1 | |
| SCHEMBL13305327 | 0.83 | GSK3B (0.45) | GSK3BCDK2CCNA2CCNA1HPGD | |
| SCHEMBL13288607 | 0.83 | GSK3B (0.52) | GSK3BCDK2CCNA2CCNA1MAPK10 | |
| SCHEMBL13305409 | 0.83 | GSK3B (0.58) | GSK3BCDK2CCNA2CCNA1MEN1 | |
| SCHEMBL12953767 | 0.82 | GSK3B (0.69) | GSK3BCDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |