Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.54 |
| ▸ | GSK3B | P49841 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119435 | 0.90 | CDK2 (0.68) | CDK2GSK3B | |
| SCHEMBL14581633 | 0.89 | CDK2 (0.49) | CDK2GSK3BMEN1KMT2APOLB | |
| SCHEMBL13288887 | 0.88 | CDK2 (0.51) | CDK2GSK3B | |
| SCHEMBL13288772 | 0.87 | CDK2 (0.53) | CDK2GSK3BHPGDMEN1KMT2A | |
| SCHEMBL13288680 | 0.87 | CDK2 (0.44) | CDK2GSK3BHPGDMEN1KMT2A | |
| SCHEMBL13288775 | 0.87 | CDK2 (0.52) | CDK2GSK3BKDM4E | |
| SCHEMBL13288668 | 0.86 | CDK2 (0.55) | CDK2GSK3BHPGDMEN1KMT2A | |
| SCHEMBL13288769 | 0.86 | CDK2 (0.55) | CDK2GSK3BHPGDMEN1KMT2A | |
| SCHEMBL13288866 | 0.86 | CDK2 (0.59) | CDK2GSK3BMEN1KMT2ANPC1 | |
| SCHEMBL13119303 | 0.85 | CDK2 (0.64) | CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |