Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288768 | 0.93 | CDK2 (0.54) | CDK2GSK3BMEN1KMT2ARAB9A | |
| SCHEMBL13288769 | 0.93 | CDK2 (0.55) | CDK2GSK3BCYP1A1HPGDPDE2A | |
| SCHEMBL13288882 | 0.91 | CDK2 (0.54) | CDK2GSK3BNAMPTPDE2APDE10A | |
| SCHEMBL13119461 | 0.90 | CDK2 (0.70) | CDK2GSK3B | |
| SCHEMBL13289698 | 0.89 | CDK2 (0.56) | CDK2GSK3BNAMPTMEN1KMT2A | |
| SCHEMBL13289148 | 0.88 | CDK2 (0.52) | CDK2GSK3BPDE2APDE10AMEN1 | |
| SCHEMBL13288775 | 0.88 | CDK2 (0.52) | CDK2GSK3BPDE2APDE10A | |
| SCHEMBL13288866 | 0.87 | CDK2 (0.59) | CDK2GSK3BMEN1KMT2ARAB9A | |
| SCHEMBL13289235 | 0.87 | CDK2 (0.45) | CDK2GSK3BNAMPTHPGDKMT2A | |
| SCHEMBL13288782 | 0.86 | CDK2 (0.54) | CDK2GSK3BHPGDTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |