Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14607249 | 0.95 | GSK3B (0.55) | GSK3BCHEK1NAMPTCDK2CYP2C9 | |
| SCHEMBL14613311 | 0.94 | GSK3B (0.53) | GSK3BCHEK1NAMPTCDK2TSHR | |
| SCHEMBL13120574 | 0.91 | GSK3B (0.68) | GSK3BCDK2 | |
| SCHEMBL13289101 | 0.90 | GSK3B (0.56) | GSK3BCHEK1NAMPTCDK2TSHR | |
| SCHEMBL13289097 | 0.89 | GSK3B (0.59) | GSK3BCHEK1NAMPTCDK2TSHR | |
| SCHEMBL14418840 | 0.89 | GSK3B (0.53) | GSK3BCHEK1NAMPTCDK2CYP2C9 | |
| SCHEMBL12953927 | 0.88 | GSK3B (0.51) | GSK3BCHEK1NAMPTCDK2 | |
| SCHEMBL12954475 | 0.88 | GSK3B (0.58) | GSK3BCHEK1NAMPTTSHRCYP2C9 | |
| SCHEMBL12953926 | 0.88 | GSK3B (0.52) | GSK3BCHEK1NAMPTCYP2C9 | |
| SCHEMBL14545257 | 0.87 | GSK3B (0.53) | GSK3BCHEK1NAMPTCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |