Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289102 | 0.90 | GSK3B (0.50) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13288942 | 0.86 | GSK3B (0.53) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289383 | 0.85 | GSK3B (0.52) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289387 | 0.85 | GSK3B (0.49) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289389 | 0.83 | GSK3B (0.53) | GSK3BCHEK1CDK2 | |
| SCHEMBL13289098 | 0.82 | GSK3B (0.51) | GSK3BCHEK1 | |
| SCHEMBL13289365 | 0.81 | GSK3B (0.54) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13288941 | 0.81 | KMT2A (0.55) | GSK3BCHEK1 | |
| SCHEMBL13288944 | 0.80 | GSK3B (0.48) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13289381 | 0.79 | GSK3B (0.64) | GSK3BCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |