Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.52 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.35 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.35 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119424 | 0.90 | CDK2 (0.66) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13288668 | 0.88 | CDK2 (0.55) | CDK2GSK3BPDE2APDE10AMEN1 | |
| SCHEMBL13288769 | 0.88 | CDK2 (0.55) | CDK2GSK3BPDE2APDE10ACCNA2 | |
| SCHEMBL13288809 | 0.88 | CDK2 (0.43) | CDK2GSK3BALDH1A1PDE2A | |
| SCHEMBL13288882 | 0.87 | CDK2 (0.54) | CDK2GSK3BPDE2APDE10A | |
| SCHEMBL13288768 | 0.87 | CDK2 (0.54) | CDK2GSK3BMEN1KMT2ACCNE1 | |
| SCHEMBL13289144 | 0.87 | CDK2 (0.54) | CDK2GSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL13119275 | 0.85 | CDK2 (0.62) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13288775 | 0.85 | CDK2 (0.52) | CDK2GSK3BPDE2APDE10AKLKB1 | |
| SCHEMBL13288866 | 0.84 | CDK2 (0.59) | CDK2GSK3BCCNA2CCNA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |