Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289124 | 0.96 | GSK3B (0.40) | GSK3BCDK2MAPTALDH1A1GAA | |
| SCHEMBL13121167 | 0.91 | GSK3B (0.49) | GSK3BCDK2MAPTALDH1A1GAA | |
| SCHEMBL13121089 | 0.90 | GSK3B (0.49) | GSK3BCDK2MAPTALDH1A1GAA | |
| SCHEMBL13289147 | 0.89 | GSK3B (0.38) | GSK3BCDK2MAPTNPSR1LMNA | |
| SCHEMBL13289007 | 0.88 | GSK3B (0.41) | GSK3BCDK2MAPT | |
| SCHEMBL13288959 | 0.88 | CDK2 (0.43) | GSK3BCDK2MAPTALDH1A1GAA | |
| SCHEMBL13121296 | 0.87 | GSK3B (0.51) | GSK3BCDK2MAPTALDH1A1GAA | |
| SCHEMBL13289301 | 0.84 | CDK2 (0.46) | GSK3BCDK2MAPTALDH1A1NPSR1 | |
| SCHEMBL13289089 | 0.83 | CDK2 (0.44) | GSK3BCDK2MAPTALDH1A1NPSR1 | |
| SCHEMBL13288981 | 0.83 | CDK2 (0.46) | GSK3BCDK2MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |