Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.43 |
| ▸ | GSK3B | P49841 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120651 | 0.92 | CDK2 (0.55) | CDK2GSK3BCCNA2CCNA1 | |
| SCHEMBL13289124 | 0.89 | GSK3B (0.40) | CDK2GSK3BLMNAALDH1A1GAA | |
| SCHEMBL13288963 | 0.89 | CDK2 (0.46) | CDK2GSK3BMAPTMEN1KMT2A | |
| SCHEMBL13289489 | 0.88 | GSK3B (0.39) | CDK2GSK3BLMNAALDH1A1GAA | |
| SCHEMBL13288974 | 0.85 | CDK2 (0.52) | CDK2GSK3BLMNAALDH1A1MEN1 | |
| SCHEMBL13289430 | 0.84 | GSK3B (0.49) | CDK2GSK3BMEN1KMT2ACCNA2 | |
| SCHEMBL13289429 | 0.84 | CDK2 (0.49) | CDK2GSK3BSMN1; SMN2CCNA2CCNA1 | |
| SCHEMBL13288964 | 0.84 | ALDH1A1 (0.48) | CDK2GSK3BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13288977 | 0.83 | CDK2 (0.47) | CDK2GSK3BLMNAALDH1A1GAA | |
| SCHEMBL13289440 | 0.82 | CDK2 (0.51) | CDK2GSK3BLMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |