Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289494 | 0.93 | GSK3B (0.51) | GSK3BCDK2CHEK1SCD | |
| SCHEMBL13121517 | 0.90 | GSK3B (0.61) | GSK3BCDK2CCNE1 | |
| SCHEMBL13289236 | 0.87 | GSK3B (0.48) | GSK3BCHEK1RBP4 | |
| SCHEMBL14613317 | 0.85 | GSK3B (0.49) | GSK3BCDK2CHEK1CDK9CCNE1 | |
| SCHEMBL13121507 | 0.82 | GSK3B (0.66) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545243 | 0.81 | GSK3B (0.57) | GSK3BCDK2CHEK1CDK9CCNE1 | |
| SCHEMBL14418687 | 0.80 | GSK3B (0.56) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13288942 | 0.78 | GSK3B (0.53) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13289498 | 0.78 | GSK3B (0.56) | GSK3BCDK2CHEK1CCNE1 | |
| SCHEMBL13288641 | 0.77 | GSK3B (0.53) | GSK3BCDK2CHEK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |