Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 5/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | GUCY1B2 | O75343 | 5/20 | 0.31 |
| ▸ | GUCY1A2 | P33402 | 5/20 | 0.31 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.31 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329131 | 0.92 | C5AR1 (0.37) | C5AR1FFAR4GUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL1327872 | 0.90 | C5AR1 (0.39) | C5AR1AKR1C3FFAR1FFAR4HPGD | |
| SCHEMBL1329248 | 0.89 | C5AR1 (0.42) | C5AR1KDM4EL3MBTL1 | |
| SCHEMBL1328029 | 0.89 | C5AR1 (0.39) | C5AR1L3MBTL1MRGPRX4GUCY1B2GUCY1A2 | |
| SCHEMBL1327779 | 0.88 | L3MBTL1 (0.46) | C5AR1KDM4EL3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL1327830 | 0.88 | MAPT (0.39) | C5AR1KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL1328614 | 0.88 | MRGPRX4 (0.40) | C5AR1AKR1C3FFAR1FFAR4KDM4E | |
| SCHEMBL1327952 | 0.88 | KDM4E (0.41) | C5AR1FFAR1FFAR4KDM4EL3MBTL1 | |
| SCHEMBL1328381 | 0.88 | FFAR4 (0.41) | C5AR1FFAR1FFAR4KDM4EL3MBTL1 | |
| SCHEMBL1329312 | 0.87 | C5AR1 (0.40) | C5AR1AKR1C3FFAR1FFAR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | claimed |
| US-20110281837-A1 | 3-SUBSTITUTED-6-ARYL PYRIDINES | HUTCHINSON ALAN J (US) | 2011-11-17 | — | — | US | disclosed |
| US-7863454-B2 | 3-substituted-6-aryl pyridines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2011-01-04 | — | — | US | disclosed |
| US-20090176980-A1 | 3-Substituted-6-Aryl Pyridines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2009-07-09 | — | — | US | disclosed |
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281837-A1 | 3-SUBSTITUTED-6-ARYL PYRIDINES | C3AR1, C5AR1, C5AR2 | C5AR1 2/4885P2RX3 20/4885AKR1C3 215/4885 |
| US-20090176980-A1 | 3-Substituted-6-Aryl Pyridines | C3AR1, C5AR1, C5AR2 | C5AR1 2/4885P2RX3 20/4885AKR1C3 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.