Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.71 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13290490 | 0.93 | CALCRL (0.68) | CALCRLRAMP1KCNH2 | |
| SCHEMBL13290489 | 0.89 | CALCRL (0.67) | CALCRLRAMP1KCNH2 | |
| SCHEMBL1435919 | 0.88 | CALCRL (0.66) | CALCRLRAMP1KCNH2 | |
| SCHEMBL1435920 | 0.88 | CALCRL (0.66) | CALCRLRAMP1KCNH2 | |
| SCHEMBL1434748 | 0.87 | CALCRL (0.64) | CALCRLRAMP1KCNH2 | |
| SCHEMBL1435837 | 0.87 | CALCRL (0.64) | CALCRLRAMP1KCNH2 | |
| SCHEMBL13481974 | 0.86 | CALCRL (0.78) | CALCRLRAMP1KCNH2 | |
| SCHEMBL1434906 | 0.86 | CALCRL (0.63) | CALCRLRAMP1KCNH2 | |
| SCHEMBL12219708 | 0.85 | CALCRL (0.86) | CALCRLRAMP1KCNH2 | |
| SCHEMBL13481983 | 0.83 | CALCRL (0.71) | CALCRLRAMP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745427-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |
| US-7745427-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2010-06-29 | — | — | US | disclosed |