Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435920 | 1.00 | CALCRL (0.66) | CALCRLKCNH2RAMP1 | |
| SCHEMBL13481983 | 0.88 | CALCRL (0.71) | CALCRLKCNH2RAMP1 | |
| SCHEMBL13290488 | 0.88 | CALCRL (0.71) | CALCRLKCNH2RAMP1 | |
| SCHEMBL13290489 | 0.86 | CALCRL (0.67) | CALCRLKCNH2RAMP1 | |
| SCHEMBL13290490 | 0.85 | CALCRL (0.68) | CALCRLKCNH2RAMP1 | |
| SCHEMBL1435837 | 0.84 | CALCRL (0.64) | CALCRLKCNH2RAMP1 | |
| SCHEMBL1434748 | 0.84 | CALCRL (0.64) | CALCRLKCNH2RAMP1 | |
| SCHEMBL13481974 | 0.83 | CALCRL (0.78) | CALCRLKCNH2RAMP1 | |
| SCHEMBL12219705 | 0.82 | CALCRL (0.80) | CALCRLKCNH2RAMP1 | |
| SCHEMBL1434906 | 0.81 | CALCRL (0.63) | CALCRLKCNH2RAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804919-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2011-03-30 | — | — | EP | disclosed |