SCHEMBL13290607

SCHEMBL13290607

O=C(Nc1ccc(F)cn1)c1oc2cccnc2c1NC(=O)[C@H]1CC[C@H](N2CCOCC2=O)CC1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ NPY5R Q15761 14/20 0.44
▸ POLB P06746 1/20 0.42
▸ MAPT P10636 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.38
▸ NPC1 O15118 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ PKM P14618 1/20 0.37
▸ RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2947435 0.91 F10 (0.41) NPY5RKDM4EMEN1TSHRKMT2A
SCHEMBL2949912 0.91 MAPK1 (0.46) NPY5RPOLBMAPTMEN1TSHR
SCHEMBL2947431 0.91 F10 (0.41) NPY5RKDM4EMEN1TSHRKMT2A
SCHEMBL2949907 0.91 MAPK1 (0.46) NPY5RPOLBMAPTMEN1TSHR
SCHEMBL13290909 0.90 POLB (0.54) NPY5RPOLBMAPTKDM4EMEN1
SCHEMBL13290611 0.89 KMT2A (0.44) NPY5RMAPTKDM4EMEN1TSHR
SCHEMBL13290695 0.88 NPY5R (0.39) NPY5RMAPTKDM4EMEN1KMT2A
SCHEMBL13290693 0.86 MEN1 (0.52) POLBMAPTKDM4EMEN1TSHR
SCHEMBL2949749 0.85 MEN1 (0.44) POLBMAPTKDM4EMEN1TSHR
SCHEMBL2949751 0.85 MEN1 (0.44) POLBMAPTKDM4EMEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7737161-B2 Condensed furan compounds MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-06-15 — — US disclosed
US-7737161-B2 Condensed furan compounds MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-06-15 — — US disclosed
US-20090156803-A1 Condensed furan compounds KAWAGUCHI TAKAYUKI 2009-06-18 — — US disclosed
US-20090156803-A1 Condensed furan compounds KAWAGUCHI TAKAYUKI 2009-06-18 — — US disclosed
US-7514449-B2 Fused furan compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-04-07 — — US disclosed
US-7514449-B2 Fused furan compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156803-A1 Condensed furan compounds F2, F12, F11 NPY5R 805/4885POLB 2463/4885MAPT 4817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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