Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HCK | P08631 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | LYN | P07948 | 4/20 | 0.46 |
| ▸ | INSR | P06213 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1825447 | 0.91 | HCK (0.46) | NPC1RAB9AHCKLCKLYN | |
| SCHEMBL13269906 | 0.87 | HCK (0.42) | RAB9AHCKLCKLYNINSR | |
| SCHEMBL1823112 | 0.86 | HCK (0.49) | HCKLCKLYNINSRSRC | |
| SCHEMBL3232951 | 0.86 | LCK (0.56) | HCKLCKLYNINSRSRC | |
| SCHEMBL1829414 | 0.86 | LCK (0.49) | HCKLCKLYNINSRSRC | |
| SCHEMBL1846255 | 0.85 | HCK (0.46) | NPC1RAB9AHCKLCKLYN | |
| SCHEMBL1825890 | 0.85 | LCK (0.52) | NPC1RAB9AHCKLCKLYN | |
| SCHEMBL1822389 | 0.85 | MAPK14 (0.53) | HCKLCKLYNINSRSRC | |
| SCHEMBL1823572 | 0.84 | HCK (0.46) | HCKLCKLYNINSRSRC | |
| SCHEMBL13292000 | 0.84 | HCK (0.47) | HCKLCKLYNINSRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |