Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | LYN | P07948 | 7/20 | 0.52 |
| ▸ | SRC | P12931 | 7/20 | 0.52 |
| ▸ | INSR | P06213 | 6/20 | 0.52 |
| ▸ | HCK | P08631 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232951 | 0.89 | LCK (0.56) | LCKKDRLYNSRCINSR | |
| SCHEMBL1829414 | 0.88 | LCK (0.49) | LCKKDRLYNSRCINSR | |
| SCHEMBL1822389 | 0.88 | MAPK14 (0.53) | LCKKDRLYNSRCINSR | |
| SCHEMBL1824965 | 0.88 | LYN (0.58) | LCKKDRLYNSRCINSR | |
| SCHEMBL1823112 | 0.87 | HCK (0.49) | LCKKDRLYNSRCINSR | |
| SCHEMBL13269757 | 0.87 | HCK (0.45) | LCKKDRLYNSRCINSR | |
| SCHEMBL19153235 | 0.85 | INSR (0.54) | LCKKDRLYNSRCINSR | |
| SCHEMBL13301785 | 0.85 | SRC (0.48) | LCKKDRLYNSRCINSR | |
| SCHEMBL3238280 | 0.85 | BRAF (0.57) | LCKKDRLYNSRCINSR | |
| SCHEMBL13292002 | 0.85 | NPC1 (0.47) | LCKKDRLYNSRCINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4688876-B2 | — | — | 2011-05-25 | — | — | JP | claimed |
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |