Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 7/20 | 0.47 |
| ▸ | FEN1 | P39748 | 7/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | DNASE1 | P24855 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13174750 | 0.99 | KMT2A (0.48) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13174725 | 0.96 | KMT2A (0.49) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13174752 | 0.91 | KMT2A (0.51) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13174903 | 0.86 | ERCC1 (0.52) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13296832 | 0.84 | KMT2A (0.47) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13296823 | 0.82 | ERCC1 (0.48) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13211359 | 0.81 | ERCC1 (0.54) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13296868 | 0.78 | HDAC3 (0.40) | ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL13174891 | 0.77 | ERCC1 (0.50) | KMT2AERCC1FEN1ERCC4ALDH1A1 | |
| SCHEMBL13174731 | 0.76 | MAPT (0.54) | KMT2AERCC1FEN1ERCC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2223921-B1 | 2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents | SHANGHAI INST MATERIA MEDICA (CN) | 2013-01-09 | — | — | EP | disclosed |
| US-7741348-B2 | Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2010-06-22 | — | — | US | disclosed |
| US-20080306121-A1 | Bisheterocycle Tandem Compounds Useful as Antiviral Agents, the Uses Thereof and the Compositions Comprising Such Compounds | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306121-A1 | Bisheterocycle Tandem Compounds Useful as Antiviral Agents, the Uses Thereof and the Compositions Comprising Such Compounds | PCNA, HAVCR2, HCCS | KMT2A 2664/4885ERCC1 235/4885FEN1 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.