Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13896433 | 0.77 | PDE10A (0.40) | KDM4ETP53PSDNPC1RAB9A | |
| SCHEMBL24695991 | 0.76 | HPGD (0.42) | KDM4ENPC1RAB9A | |
| SCHEMBL24695811 | 0.76 | HPGD (0.42) | KDM4ENPC1RAB9A | |
| SCHEMBL5056012 | 0.75 | RAB9A (0.44) | KDM4ENPC1RAB9A | |
| SCHEMBL544920 | 0.75 | RAB9A (0.45) | KDM4ETP53NPC1RAB9A | |
| SCHEMBL22175826 | 0.74 | HRH4 (0.34) | HRH4 | |
| SCHEMBL5466448 | 0.74 | PDE10A (0.56) | TP53PSDMAPK8BTKMRGPRX2 | |
| SCHEMBL13305063 | 0.74 | PSD (0.40) | KDM4EPSDNPC1RAB9ATLR8 | |
| SCHEMBL1934522 | 0.73 | PDE10A (0.48) | KDM4ETP53NPC1RAB9APDE10A | |
| SCHEMBL22176506 | 0.72 | GAA (0.35) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741318-B2 | Pyrazolo [1,5-A]pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741318-B2 | Pyrazolo [1,5-A]pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1836205-B1 | PYRAZOLO[1,5-A]PYRIMIDINE ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2009-06-10 | — | — | EP | disclosed |