Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13298079 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2LMNAMAPK1POLBKDM4E | |
| SCHEMBL13298086 | 0.85 | POLB (0.42) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL13317615 | 0.84 | POLB (0.41) | SMN1; SMN2LMNAMAPK1POLBKDM4E | |
| SCHEMBL13298153 | 0.80 | KMT2A (0.48) | L3MBTL1SMN1; SMN2LMNAMAPK1POLB | |
| SCHEMBL13298080 | 0.79 | JAK2 (0.52) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL13298082 | 0.78 | POLB (0.42) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL13298152 | 0.78 | KMT2A (0.44) | SMN1; SMN2LMNAMAPK1POLBKDM4E | |
| SCHEMBL13298085 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAMAPK1POLBKDM4E | |
| SCHEMBL13298046 | 0.77 | POLB (0.46) | SMN1; SMN2LMNAPOLBALDH1A1CDK2 | |
| SCHEMBL13298148 | 0.77 | GSK3B (0.42) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741318-B2 | Pyrazolo [1,5-A]pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1836205-B1 | PYRAZOLO[1,5-A]PYRIMIDINE ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2009-06-10 | — | — | EP | disclosed |