Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 6/20 | 0.59 |
| ▸ | CSF1R | P07333 | 5/20 | 0.59 |
| ▸ | FLT1 | P17948 | 5/20 | 0.59 |
| ▸ | KIT | P10721 | 5/20 | 0.59 |
| ▸ | FLT4 | P35916 | 4/20 | 0.59 |
| ▸ | AURKA | O14965 | 4/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.59 |
| ▸ | STK3 | Q13188 | 2/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.59 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.59 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331383 | 0.89 | KDR (0.72) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1330844 | 0.87 | KDR (0.69) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1331347 | 0.87 | KDR (0.69) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL423310 | 0.87 | KDR (0.73) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1331628 | 0.86 | KDR (0.66) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1331629 | 0.86 | KDR (0.66) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1331714 | 0.86 | KDR (0.70) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1332041 | 0.85 | KDR (0.69) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1331624 | 0.84 | KDR (0.71) | KDRNTRK1FLT3CSF1RFLT1 | |
| SCHEMBL1329799 | 0.84 | KDR (0.66) | KDRNTRK1FLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569301-A1 | INDAZOLE INHIBITORS OF KINASE | Abbvie Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| WO-2011143430-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | WO | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | KDR 11/4885NTRK1 805/4885FLT3 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.