Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.69 |
| ▸ | AXL | P30530 | 9/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 7/20 | 0.54 |
| ▸ | FLT1 | P17948 | 7/20 | 0.54 |
| ▸ | KIT | P10721 | 7/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.54 |
| ▸ | AURKA | O14965 | 5/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.54 |
| ▸ | STK3 | Q13188 | 4/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.54 |
| ▸ | PLK4 | O00444 | 4/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.54 |
| ▸ | FYN | P06241 | 4/20 | 0.54 |
| ▸ | LYN | P07948 | 4/20 | 0.54 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330486 | 0.95 | KDR (0.62) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1330301 | 0.90 | AXL (0.60) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1331695 | 0.90 | AURKB (0.61) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1331637 | 0.88 | KDR (0.64) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1330237 | 0.87 | FGFR1 (0.70) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1330136 | 0.86 | AXL (0.62) | KDRAXLFGFR1DDR2AURKB | |
| SCHEMBL1331362 | 0.85 | FGFR1 (0.62) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1329774 | 0.85 | FGFR1 (0.55) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1331464 | 0.85 | KDR (0.62) | KDRAXLNTRK1FGFR1DDR2 | |
| SCHEMBL1330072 | 0.85 | KDR (0.75) | KDRAXLNTRK1FGFR1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | KDR 11/4885AXL 399/4885NTRK1 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.