Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 6/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | INSR | P06213 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 3/20 | 0.54 |
| ▸ | HCK | P08631 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 7/20 | 0.50 |
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | BCR | P11274 | 4/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301945 | 0.94 | HCK (0.61) | LYNSRCINSRLCKHCK | |
| SCHEMBL1841758 | 0.90 | BRAF (0.61) | LYNSRCABL1BRAFEGFR | |
| SCHEMBL13301943 | 0.89 | BRAF (0.51) | LYNSRCINSRLCKHCK | |
| SCHEMBL14097742 | 0.85 | BRAF (0.49) | LYNSRCABL1BRAFEGFR | |
| SCHEMBL1824771 | 0.85 | HCK (0.63) | LYNSRCINSRLCKHCK | |
| SCHEMBL13302014 | 0.84 | HCK (0.53) | LYNSRCINSRLCKHCK | |
| SCHEMBL13301721 | 0.83 | MAPK14 (0.50) | LYNSRCINSRLCKHCK | |
| SCHEMBL13301899 | 0.83 | HCK (0.48) | LYNSRCINSRLCKHCK | |
| SCHEMBL13291960 | 0.83 | BRAF (0.56) | LYNSRCINSRLCKHCK | |
| SCHEMBL13269709 | 0.83 | CSF1R (0.55) | LYNSRCINSRLCKHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745437-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-06-29 | — | — | US | disclosed |