Honokiol

Honokiol

SCHEMBL133034

C=CCc1ccc(O)c(-c2ccc(O)c(CC=C)c2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 12/20 1.00
GABRB2 P47870 12/20 1.00
ALOX5 P09917 8/20 1.00
CNR2 P34972 5/20 1.00
CNR1 P21554 3/20 1.00
MEN1 O00255 2/20 1.00
GAA P10253 2/20 1.00
MAPT P10636 2/20 1.00
KMT2A Q03164 2/20 1.00
POLB P06746 1/20 1.00
GABRB1 P18505 1/20 1.00
RXRA P19793 1/20 1.00
GABRA5 P31644 1/20 1.00
GABRA3 P34903 1/20 1.00
GABRA2 P47869 1/20 1.00
ACE2 Q9BYF1 1/20 1.00
SIRT3 Q9NTG7 1/20 1.00
AKR1B1 P15121 2/20 0.69
KDM4E B2RXH2 1/20 0.69
ALDH1A1 P00352 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Honokiol SCHEMBL29363985 1.00 GABRA1 (1.00) GABRA1GABRB2ALOX5CNR2CNR1
Honokiol SCHEMBL29384099 1.00 GABRA1 (1.00) GABRA1GABRB2ALOX5CNR2CNR1
Honokiol SCHEMBL16011724 1.00 GABRA1 (1.00) GABRA1GABRB2ALOX5CNR2CNR1
Honokiol SCHEMBL30008303 1.00 GABRA1 (1.00) GABRA1GABRB2ALOX5CNR2CNR1
Magnolol SCHEMBL527731 0.98 GABRA1 (0.97) GABRA1GABRB2ALOX5CNR2CNR1
Honokiol SCHEMBL23245947 0.92 GABRA1 (0.84) GABRA1GABRB2ALOX5CNR2CNR1
SCHEMBL13978626 0.90 GABRA1 (0.82) GABRA1GABRB2ALOX5CNR2CNR1
SCHEMBL29492181 0.90 GABRA1 (0.81) GABRA1GABRB2ALOX5CNR2CNR1
SCHEMBL18787321 0.89 GABRA1 (0.81) GABRA1GABRB2ALOX5CNR2CNR1
SCHEMBL18793822 0.89 GABRA1 (0.81) GABRA1GABRB2ALOX5CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9565 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748368-A1 COMPOSITION FOR ORAL HYGIENE PRODUCTS COMPRISING N-CETYLPYRIDINIUM CHLORIDE, A FLAVONOID AND A POLYMER Curaden AG (CH) 2026-05-27 EP claimed
EP-4743565-A2 CYTOKINE ENCODING LENTIVIRAL VECTORS AND USES THEREOF FOR MAKING TUMOR INFILTRATING LYMPHOCYTES Iovance Biotherapeutics, Inc. (US) 2026-05-20 EP claimed
CN-121337636-B Liposome with lipase responsiveness, preparation method, application and product thereof 广州科盈化妆品有限公司 2026-05-15 CN claimed
EP-4740932-A2 COSMETIC COMPOSITION FOR SKIN IMPROVEMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SKIN DAMAGE, EACH CONTAINING HONOKIOL AND POLYOL Cosmax, Inc. (KR) 2026-05-13 EP claimed
CN-122005674-A Formula for treating nocardia of fish and preparation method thereof 广西壮族自治区水产科学研究院(广西壮族自治区渔业病害防治环境监测和质量检验中心、广西壮族自治区水生野生动物救护中心) 2026-05-12 CN claimed
CN-122011022-A Honokiol phosphine salt derivative and preparation method and application thereof 遵义医科大学 2026-05-12 CN claimed
CN-122010764-A Honokiol derivative with cationic group, preparation method thereof and application thereof in preparation of anti-infective medicament 遵义医科大学 2026-05-12 CN claimed
EP-4734945-A1 WASH COMPOSITION WITH ANIONIC SULFATE AND SULTAINE NOT RELIANT ON PALM KERNEL OIL Unilever IP Holdings B.V. (NL) 2026-05-06 EP claimed
WO-2026087680-A1 TREATMENT FOR CARDIOVASCULAR DISEASE SAPREME TECHNOLOGIES B.V. (NL) 2026-04-30 WO claimed
WO-2026087695-A1 TREATMENT FOR METABOLIC DISORDER SAPREME TECHNOLOGIES B.V. (NL) 2026-04-30 WO claimed
CN-1362395-A Method of refining effective component of official magnolia GUANGZHOU MEICHEN PHARAMACEUTI (CN) 2002-08-07 CN claimed
US-20020076456-A1 Compositions and methods of use for extracts of magnoliaceae plants INTERHEALTH NUTRACEUTICALS INCORPORATED 2002-06-20 US claimed
WO-2001085116-A2 SYNERGISTIC ANTIPLAQUE/ANTIGINGIVITIS ORAL COMPOSITION COLGATE-PALMOLIVE COMPANY (US) 2001-11-15 WO claimed
WO-2001082922-A1 ORAL COMPOSITIONS COMPRISING POLYPHENOL HERBAL EXTRACTS THE PROCTER & GAMBLE COMPANY (US) 2001-11-08 WO claimed
CN-1318362-A Caries preventing Magnolia Officinalis toothpaste WUHAN CHEMICAL PLANT WUHAN (CN) 2001-10-24 CN claimed
EP-1140756-A2 SYNTHESIS OF DIHYDROHONOKIOL COMPOSITIONS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2001-10-10 EP claimed
WO-2000040532-A2 SYNTHESIS OF DIHYDROHONOKIOL COMPOSITIONS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2000-07-13 WO claimed
EP-0991614-A1 SYNTHESIS OF DIHYDROHONOKIOL COMPOSITIONS Board of Regents, The University of Texas System (US) 2000-04-12 EP claimed
WO-1999000346-A1 SYNTHESIS OF DIHYDROHONOKIOL COMPOSITIONS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1999-01-07 WO claimed
CN-85103128-A The extracting method of magnolol and Honokiol 1987-02-04 CN claimed