Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CDK7 | P50613 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNH | P51946 | 3/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304927 | 1.00 | GSK3B (0.56) | GSK3BCHEK1CDK2CDK7CCNE1 | |
| SCHEMBL12952900 | 0.89 | GSK3B (0.71) | GSK3BCDK2CCNE1 | |
| SCHEMBL12952850 | 0.89 | GSK3B (0.71) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545791 | 0.89 | GSK3B (0.56) | GSK3BCHEK1CDK2CDK7CCNE1 | |
| SCHEMBL12954560 | 0.88 | GSK3B (0.56) | GSK3BCHEK1CDK2CCNE1MAPKAPK2 | |
| SCHEMBL13289627 | 0.84 | GSK3B (0.54) | GSK3BCDK2CCNE1MAPKAPK2 | |
| SCHEMBL14545294 | 0.83 | GSK3B (0.64) | GSK3BCDK2CCNE1 | |
| SCHEMBL13146283 | 0.83 | GSK3B (0.81) | GSK3BCHEK1CDK2CCNE1CDK9 | |
| SCHEMBL13146410 | 0.82 | GSK3B (0.79) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL12954504 | 0.82 | GSK3B (0.56) | GSK3BCDK2CDK7CCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |