Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.47 |
| ▸ | CCNH | P51946 | 3/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12952900 | 0.89 | GSK3B (0.71) | GSK3BCDK2CCNE1 | |
| SCHEMBL12952850 | 0.89 | GSK3B (0.71) | GSK3BCDK2CCNE1 | |
| SCHEMBL13304614 | 0.89 | GSK3B (0.56) | GSK3BCHEK1CDK7CDK2CDK1 | |
| SCHEMBL13304927 | 0.89 | GSK3B (0.56) | GSK3BCHEK1CDK7CDK2CDK1 | |
| SCHEMBL13305571 | 0.85 | MAPKAPK2 (0.60) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305295 | 0.83 | GSK3B (0.81) | GSK3BCHEK1CDK2 | |
| SCHEMBL13304607 | 0.82 | GSK3B (0.79) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14545868 | 0.82 | GSK3B (0.58) | GSK3BCDK7CDK2CDK1CCNE1 | |
| SCHEMBL13305360 | 0.80 | GSK3B (0.54) | GSK3BCHEK1CDK7CDK2CCNE1 | |
| SCHEMBL14545919 | 0.80 | GSK3B (0.54) | GSK3BCHEK1CDK7CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |