Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953050 | 0.83 | GSK3B (0.52) | HSP90AA1HSP90AB1HSD11B1KDM4EMAPT | |
| SCHEMBL13305024 | 0.83 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL13304770 | 0.77 | CDK2 (0.47) | HSD11B1KDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL13304790 | 0.75 | MAPT (0.57) | KDM4EALDH1A1MAPTRAB9AHPGD | |
| SCHEMBL13650606 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTRAB9AHPGD | |
| SCHEMBL12953049 | 0.72 | PDE10A (0.58) | HSP90AA1HSP90AB1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL19455177 | 0.72 | MAPT (0.59) | KDM4EALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL13304823 | 0.71 | MAPT (0.41) | KDM4EALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL13304775 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL21754311 | 0.69 | KDM4E (0.42) | KDM4EALDH1A1MAPTRAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |