Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.58 |
| ▸ | GSK3B | P49841 | 6/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305418 | 0.90 | CDK2 (0.63) | CDK2GSK3BABL1MEN1KMT2A | |
| SCHEMBL14301243 | 0.89 | GSK3B (0.48) | CDK2GSK3BABL1MEN1KMT2A | |
| SCHEMBL12953754 | 0.88 | CDK2 (0.75) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13289158 | 0.88 | CDK2 (0.63) | CDK2GSK3BMEN1KMT2ANPC1 | |
| SCHEMBL13305297 | 0.86 | CDK2 (0.77) | CDK2GSK3BMEN1KMT2ANPC1 | |
| SCHEMBL13305311 | 0.85 | GSK3B (0.79) | CDK2GSK3BCCNE1CYP1A2CYP3A4 | |
| SCHEMBL13305640 | 0.82 | CDK2 (0.54) | CDK2GSK3BMEN1KMT2ANPC1 | |
| SCHEMBL12954471 | 0.81 | GSK3B (0.55) | CDK2GSK3BMEN1KMT2ANPC1 | |
| SCHEMBL14607199 | 0.81 | CDK2 (0.51) | CDK2GSK3BABL1MEN1KMT2A | |
| SCHEMBL13305690 | 0.81 | CDK2 (0.53) | CDK2GSK3BMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |