Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.55 |
| ▸ | CDK2 | P24941 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304619 | 0.89 | GSK3B (0.55) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305020 | 0.87 | GSK3B (0.55) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305640 | 0.87 | CDK2 (0.54) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL12953603 | 0.87 | CDK2 (0.70) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL13304993 | 0.87 | CDK2 (0.53) | GSK3BCDK2MEN1KMT2ACCNA2 | |
| SCHEMBL14546042 | 0.85 | GSK3B (0.51) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13289158 | 0.85 | CDK2 (0.63) | GSK3BCDK2MEN1KMT2ACCNA2 | |
| SCHEMBL13305418 | 0.83 | CDK2 (0.63) | GSK3BCDK2MEN1KMT2ACCNA2 | |
| SCHEMBL13305297 | 0.83 | CDK2 (0.77) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13304831 | 0.81 | CDK2 (0.58) | GSK3BCDK2MEN1KMT2ACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |