Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.55 |
| ▸ | CDK2 | P24941 | 9/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | GPR39 | O43194 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305161 | 0.88 | GSK3B (0.56) | GSK3BCDK2CCNA2CCNA1GPR39 | |
| SCHEMBL12954218 | 0.88 | GSK3B (0.72) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL30356813 | 0.78 | GSK3B (0.70) | GSK3BCDK2CCNE1MEN1KMT2A | |
| SCHEMBL12953359 | 0.76 | GSK3B (0.69) | GSK3BCDK2CCNE1MEN1KMT2A | |
| SCHEMBL14607047 | 0.75 | CDK2 (0.77) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL12953362 | 0.75 | CDK2 (0.68) | GSK3BCDK2CCNE1 | |
| SCHEMBL27369472 | 0.74 | GSK3B (0.76) | GSK3BCDK2CCNE1MEN1KMT2A | |
| SCHEMBL13305604 | 0.74 | GSK3B (0.59) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL13117880 | 0.74 | GSK3B (0.76) | GSK3BCDK2CCNE1CCNA2CCNA1 | |
| SCHEMBL27382750 | 0.74 | GSK3B (0.54) | GSK3BCDK2CCNE1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |