Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.62 |
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13146283 | 0.82 | GSK3B (0.81) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL12953000 | 0.82 | GSK3B (1.00) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13305295 | 0.82 | GSK3B (0.81) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13304869 | 0.72 | GSK3B (0.77) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL12953591 | 0.72 | GSK3B (0.98) | GSK3BCDK2CCNE1 | |
| SCHEMBL13304607 | 0.71 | GSK3B (0.79) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13146410 | 0.71 | GSK3B (0.79) | GSK3BCHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL12952914 | 0.71 | GSK3B (1.00) | GSK3BCDK2CCNE1 | |
| SCHEMBL12952848 | 0.71 | GSK3B (1.00) | GSK3BCDK2CCNE1 | |
| SCHEMBL13845547 | 0.70 | CHEK1 (0.76) | GSK3BCHEK1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |