Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.81 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.75 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953000 | 0.89 | GSK3B (1.00) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13146283 | 0.89 | GSK3B (0.81) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13304607 | 0.89 | GSK3B (0.79) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13305375 | 0.84 | GSK3B (0.57) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14545791 | 0.83 | GSK3B (0.56) | GSK3BCHEK1CDK2 | |
| SCHEMBL14050830 | 0.82 | GSK3B (0.68) | GSK3BCHEK1CDK2 | |
| SCHEMBL13304931 | 0.82 | GSK3B (0.69) | GSK3BCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL13116990 | 0.80 | GSK3B (0.59) | GSK3BCHEK1CDK2 | |
| SCHEMBL14545949 | 0.80 | GSK3B (0.60) | GSK3BCHEK1CDK2 | |
| SCHEMBL13304919 | 0.80 | GSK3B (0.62) | GSK3BCHEK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |