Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 15/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14597901 | 0.89 | GSK3B (0.69) | MAPKAPK2GSK3BCDK2CCNE1 | |
| SCHEMBL12952892 | 0.89 | GSK3B (0.69) | MAPKAPK2GSK3BCDK2CCNE1 | |
| SCHEMBL14545791 | 0.85 | GSK3B (0.56) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545868 | 0.83 | GSK3B (0.58) | GSK3BCDK2CCNE1 | |
| SCHEMBL12953647 | 0.83 | GSK3B (0.76) | GSK3BCDK2CCNE1 | |
| SCHEMBL13305360 | 0.81 | GSK3B (0.54) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545919 | 0.81 | GSK3B (0.54) | GSK3BCDK2CCNE1 | |
| SCHEMBL14546032 | 0.81 | GSK3B (0.56) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545295 | 0.80 | GSK3B (0.61) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545811 | 0.80 | GSK3B (0.52) | GSK3BCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |