Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | CDK9 | P50750 | 7/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.49 |
| ▸ | CDK1 | P06493 | 6/20 | 0.49 |
| ▸ | CDK7 | P50613 | 7/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CCNH | P51946 | 4/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954265 | 0.89 | CDK2 (0.61) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL13116921 | 0.87 | CDK2 (0.61) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL12953834 | 0.85 | CDK2 (0.63) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL14346177 | 0.84 | MAPKAPK2 (0.42) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL12954560 | 0.83 | GSK3B (0.56) | CDK2GSK3BCCNE1MAPKAPK2 | |
| SCHEMBL13304680 | 0.79 | CDK2 (0.60) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL13116922 | 0.78 | CDK2 (0.57) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL13304828 | 0.77 | CDK7 (0.52) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL12953465 | 0.77 | CDK2 (0.55) | CDK2CDK9CDK5CDK1CDK7 | |
| SCHEMBL14276459 | 0.77 | CDK2 (0.55) | CDK2CDK9CDK5CDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |