Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429886 | 0.86 | MAPT (0.60) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL2252810 | 0.85 | MAPT (0.58) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL9364255 | 0.83 | MAPT (0.57) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL1252482 | 0.83 | MAPT (0.57) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL8529739 | 0.83 | MAPT (0.57) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL184552 | 0.83 | MAPT (0.57) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL2985242 | 0.83 | MAPT (0.57) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL16839623 | 0.83 | MAPT (0.57) | MAPTKMT2AMGLLCA1CA2 | |
| Hydrochloric Acid SCHEMBL6391948 | 0.82 | MAPT (0.55) | MAPTKMT2AMGLLCA1CA2 | |
| SCHEMBL12448459 | 0.82 | MAPT (0.55) | MAPTKMT2AMGLLCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-1740584-B9 | FUSED QUINOLINE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2010-06-09 | — | — | EP | disclosed |