Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429886 | 0.86 | MAPT (0.60) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL2252810 | 0.85 | MAPT (0.58) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL9428447 | 0.85 | CA12 (0.62) | CA1CA2CA12CA7CA9 | |
| SCHEMBL16664960 | 0.84 | PLK1 (0.49) | MAPTKMT2ATSHRMEN1CYP1A2 | |
| SCHEMBL184552 | 0.83 | MAPT (0.57) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL1252482 | 0.83 | MAPT (0.57) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL8529739 | 0.83 | MAPT (0.57) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL13306149 | 0.83 | MAPT (0.57) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL2985242 | 0.83 | MAPT (0.57) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL16839623 | 0.83 | MAPT (0.57) | MAPTKMT2ACA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | claimed |
| CN-1030074-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BECKMAN CORP (US) | 1989-01-04 | — | — | CN | claimed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | claimed |
| US-5314918-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0403249-B1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORP (US) | 1994-04-27 | — | — | EP | disclosed |
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0403249-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |
| CN-1030074-A | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BECKMAN CORP (US) | 1989-01-04 | — | — | CN | disclosed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | disclosed |