Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 17/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1330966 | 0.89 | ABCB1 (1.00) | ABCB1KCNH2 | |
| SCHEMBL29374303 | 0.88 | ABCB1 (1.00) | ABCB1KCNH2 | |
| SCHEMBL8122651 | 0.85 | KCNH2 (1.00) | ABCB1KCNH2 | |
| SCHEMBL31429551 | 0.84 | ABCB1 (0.90) | ABCB1KCNH2 | |
| SCHEMBL30590561 | 0.84 | KCNH2 (1.00) | ABCB1KCNH2 | |
| SCHEMBL29636535 | 0.84 | ABCB1 (0.79) | ABCB1KCNH2 | |
| SCHEMBL31619332 | 0.83 | KCNH2 (0.85) | ABCB1KCNH2 | |
| SCHEMBL8124293 | 0.80 | ABCB1 (0.70) | ABCB1KCNH2 | |
| SCHEMBL31619331 | 0.79 | KCNH2 (0.79) | ABCB1KCNH2 | |
| N-Depropyl-Propaphenone SCHEMBL31619339 | 0.78 | KCNH2 (1.00) | ABCB1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8323911-B2 | High throughput assay for discovering new inhibitors of the GIRK1/4 channel | UNIVERSITY OF SOUTH CAROLINA (US) | 2012-12-04 | — | — | US | disclosed |
| US-20110281278-A1 | High Throughput Assay for Discovering New Inhibitors of the GIRK1/4 Channel | UNIVERSITY OF SOUTH CAROLINA (US) | 2011-11-17 | — | — | US | disclosed |