Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | MAX | P61244 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19766160 | 0.83 | ESR1 (0.58) | ESR1ESR2CYP1A2ACHEMAPT | |
| SCHEMBL28027778 | 0.79 | ESR1 (0.50) | ESR1ESR2CYP1A2MAPTGAA | |
| SCHEMBL29499023 | 0.79 | ESR1 (0.50) | ESR1ESR2CYP1A2MAPTGAA | |
| SCHEMBL15131697 | 0.78 | ESR1 (0.57) | ESR1ESR2CYP1A2ACHEMAPT | |
| SCHEMBL29514776 | 0.78 | ESR1 (0.73) | ESR1ESR2CYP1A2ACHEMAPT | |
| SCHEMBL194068 | 0.78 | ESR1 (0.73) | ESR1ESR2CYP1A2ACHEMAPT | |
| SCHEMBL13313366 | 0.76 | CYP1A2 (0.64) | ESR1ESR2CYP1A2ACHEMAPT | |
| SCHEMBL20291573 | 0.76 | ESR1 (0.56) | ESR1ESR2CYP1A2MAPTGAA | |
| SCHEMBL29392069 | 0.76 | ESR1 (0.56) | ESR1ESR2CYP1A2MAPTGAA | |
| SCHEMBL28139140 | 0.76 | ESR1 (0.70) | ESR1ESR2CYP1A2ACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-06-24 | — | — | US | disclosed |
| US-7692011-B2 | 8-hydroxy and 8-mercapto quinazolinones | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | ACHE, PSEN1, PSEN2 | ESR1 4227/4885ESR2 4087/4885CYP1A2 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.