Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13313907 | 0.80 | HTR2A (0.42) | LMNAALDH1A1GLAMAPTEGFR | |
| SCHEMBL11617000 | 0.79 | LMNA (0.52) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL11615313 | 0.76 | LMNA (0.55) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL10920908 | 0.75 | LMNA (0.67) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL11613846 | 0.74 | GLA (0.56) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL7557801 | 0.74 | LMNA (0.45) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL11620314 | 0.72 | LMNA (0.54) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL14546086 | 0.72 | LMNA (0.62) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL18366018 | 0.71 | GLA (0.62) | LMNAMAPK1ALDH1A1THRBTSHR | |
| SCHEMBL31487688 | 0.70 | HDAC8 (0.32) | LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980907-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980907-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-8889635-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-18 | — | — | US | disclosed |
| US-8889635-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140128327-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128327-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-08 | — | — | US | disclosed |
| US-20100160299-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128327-A1 | DENDRIMER CONJUGATES | CD44, DDOST, ADGRE5 | LMNA 3032/4885MAPK1 4058/4885ALDH1A1 2133/4885 |
| US-20100160299-A1 | DENDRIMER CONJUGATES | CD44, DDOST, ADGRE5 | LMNA 3032/4885MAPK1 4058/4885ALDH1A1 2133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.