Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KCNT1 | Q5JUK3 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3221943 | 0.85 | POLB (0.78) | ALDH1A1POLBCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL13314890 | 0.85 | POLB (0.57) | ALDH1A1POLBCYP2D6CYP2C19CYP2C9 | |
| SCHEMBL13460020 | 0.84 | POLB (0.59) | ALDH1A1POLBCYP2D6CYP2C19CYP2C9 | |
| SCHEMBL4504352 | 0.84 | ALDH1A1 (0.64) | ALDH1A1POLBCYP2C19DRD4SMN1; SMN2 | |
| SCHEMBL3220294 | 0.84 | POLB (0.81) | ALDH1A1POLBCYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL13314913 | 0.83 | SMN1; SMN2 (0.72) | ALDH1A1POLBCYP2D6CYP2C19CYP2C9 | |
| SCHEMBL13459926 | 0.82 | ALDH1A1 (0.61) | ALDH1A1POLBDRD4SMN1; SMN2DRD2 | |
| SCHEMBL3203453 | 0.82 | ALDH1A1 (0.72) | ALDH1A1POLBSMN1; SMN2LMNAHTT | |
| SCHEMBL4578859 | 0.81 | ALDH1A1 (0.67) | ALDH1A1POLBDRD4SMN1; SMN2DRD2 | |
| Hydrochloric Acid SCHEMBL4576674 | 0.80 | ALDH1A1 (0.66) | ALDH1A1POLBDRD4SMN1; SMN2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737157-B2 | Pyrimidine compounds | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2010-06-15 | — | — | US | disclosed |
| WO-2010025138-A2 | PYRIMIDINE COMPOUNDS | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056512-A1 | PYRIMIDINE COMPOUNDS | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056512-A1 | PYRIMIDINE COMPOUNDS | TYMS, TYMP, DPYD | ALDH1A1 772/4885POLB 134/4885CYP2D6 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.