Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3539167 | 1.00 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL13314769 | 0.82 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3540501 | 0.82 | RAB9A (0.67) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL13314763 | 0.79 | MAPT (0.57) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3536479 | 0.79 | MAPT (0.57) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL13314905 | 0.78 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL13314888 | 0.77 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL4421639 | 0.77 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL13314762 | 0.77 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3542473 | 0.77 | RAB9A (0.44) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |