Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542463 | 1.00 | NPC1 (0.33) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL13314780 | 0.82 | NPC1 (0.35) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL3535415 | 0.82 | NPC1 (0.35) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL3536165 | 0.77 | NPC1 (0.34) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL3536663 | 0.77 | NPC1 (0.34) | NPC1RAB9APSEN1PSEN2APH1B | |
| Formic Acid SCHEMBL3536155 | 0.77 | TSHR (0.34) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL3536953 | 0.76 | XIAP (0.36) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL13349056 | 0.76 | NPC1 (0.33) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL20000890 | 0.76 | XIAP (0.32) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL3538767 | 0.76 | PSEN1 (0.33) | NPC1RAB9APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |